沙格列汀联合胰岛素治疗2型糖尿病患者的有效性及安全性评价

Evaluation of the Efficacy and Safety of Saxagliptin Combined with Insulin in Patients with Type 2 Diabetes

目的研究沙格列汀联合胰岛素治疗2型糖尿病患者的有效性及安全性。方法选取2018年1月—2019年2月来该院接受2型糖尿病治疗患者70例,运用随单双号法将患者分为观察组和对照组各35例。对照组运用胰岛素注射治疗,观察组在对照组基础上加入沙格列汀治疗。对比两组治疗有效率、治疗前后血糖水平改善情况、不良反应发生率。结果观察组治疗有效率为91.43%高于对照组71.43%(χ^2=4.629,P=0.031);治疗后,观察组空腹血糖和餐后2h血糖为(6.11±1.65)mmol/L、(7.44±2.38)mmol/L低于对照组空腹血糖和餐后2h血糖(8.27±1.83)mmol/L、(9.56±2.83)mmol/L(空腹血糖:t=5.186,P=0.000;餐后2h血糖:t=3.392,P=0.001),以上两项数据对比差异有统计学意义(P<0.05);观察组不良反应发生率为11.43%低于对照组17.14%,数据差异无统计学意义(χ^2=0.477,P=0.495>0.05)。结论沙格列汀联合胰岛素治疗2型糖尿病效果显著,可有效改善血糖水平,安全性较高,值得临床广泛推广。

Objective To study the efficacy and safety of saxagliptin combined with insulin in the treatment of type 2 diabetes.Methods Seventy patients with type 2 diabetes treated in our hospital from January 2018 to February 2019 were enrolled.The patients were divided into observation group and control group by 35 cases.The control group was treated with insulin injection,and the observation group was treated with saxagliptin on the basis of the control group.The effective rate of the two groups,the improvement of blood glucose levels before and after treatment,and the incidence of adverse reactions were compared.Results The effective rate of the observation group was 91.43% higher than that of the control group 71.43%(χ^2=4.629,P=0.031).After treatment,the fasting blood glucose and the postprandial 2 h blood glucose of the observation group were (6.11±1.65) mmol/L,(7.44±2.38) mmol/L was lower than the control group,fasting blood glucose and postprandial 2 h blood glucose(8.27±1.83) mmol/L,(9.56±2.83) mmol/L (fasting blood glucose: t=5.186,P=0.000;2 h postprandial blood glucose: t=3.392,P=0.001),the difference between the above two data was statistically significant (P<0.05);the incidence of adverse reactions in the observation group was 11.43% lower than that in the control group 17.14%,the data were not statistically significant (χ^2=0.477,P=0.495>0.05).Conclusion Saxagliptin combined with insulin in the treatment of type 2 diabetes is effective,can effectively improve blood sugar levels,and has high safety.It is worthy of widespread clinical promotion.