长链非编码RNA调节肿瘤细胞糖代谢的研究进展

Progress in long non-coding RNA regulating glucose metabolism in tumor cells

细胞内能量代谢异常是肿瘤的十大特征之一。肿瘤细胞主要通过Warburg效应提供能量,从而实现快速增殖和侵袭,这是目前肿瘤诊断的一个重要理论基础。长链非编码RNA(long non-coding RNA,lncRNA)可以在基因转录、表观遗传学和转录后水平等方面发挥重要的调控作用,并且通过与其他大分子相互作用来调控细胞的增殖、迁移、侵袭和凋亡等生物学过程。近年来,随着研究深入,人们发现lncRNA对肿瘤微环境具有调节作用,其中主要影响肿瘤的糖代谢水平。本文从信号通路、代谢酶及基因3个方面总结近年来有关肿瘤糖代谢中lncRNA作用机制的研究进展,以期为肿瘤临床治疗提供新的靶点及预后标志物。

Abnormal intracellular energy metabolism is one of the ten characteristics of tumors. Tumor cells mainly achieve energy through the Warburg effect to proliferate and invade rapidly, which is an important theoretical foundation for tumor diagnosis. Many studies have indicated that long non-coding RNAs(lncRNAs) play a key role in the regulation of gene transcription, epigenetics and posttranscriptional level, and regulate the proliferation, differentiation, migration and apoptosis of tumor cells through interaction with other cellular macromolecules. In recent years, the further researches show that LncRNA plays a regulatory role in tumor microenvironment, which mainly affects the level of glucose metabolism in tumors. Therefore, the paper summarizes the progess in the mechanism of lncRNA action in tumor glucose metabolism from three aspects including signaling pathway, metabolic enzymes and genes, in order to provide new targets and prognostic markers for the clinical treatment of tumors.