胎龄不超过32周早产儿血浆中性粒细胞明胶酶相关载脂蛋白的表达及其与支气管肺发育不良的关系被引量：10

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摘要支气管肺发育不良(BPD)是早产儿常见且严重的并发症,对早产儿近期和远期结局有重要影响.BPD的发生与早产、极低出生体重、胎儿期胎盘低灌注、宫内缺氧、妊娠期高血压、表面活性蛋白(SP)基因多态性等因素有关,其病理过程主要涉及炎性反应、氧化应激、免疫反应、气道壁重构、间质纤维化、肺动脉高压等.中性粒细胞明胶酶相关载脂蛋白(NGAL)与急性肺损伤和感染的发生有关,但其与新生儿BPD发生、发展的关系目前国内罕有报道.本研究通过检测胎龄≤32周的早产儿血浆NGAL的表达,探讨其与BPD的关系.

作者常绍鸿张卫星栾斌

机构地区新乡市中心医院儿科郑州大学第三附属医院儿科

出处《上海医学》 CAS 北大核心 2019年第3期185-186,共2页 Shanghai Medical Journal

关键词中性粒细胞明胶酶相关载脂蛋白支气管肺发育不良早产儿血浆胎龄极低出生体重妊娠期高血压表面活性蛋白

分类号 R722.6 [医药卫生—儿科]

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