维生素B12缺乏与不自主运动

Vitamin B12 deficiency and involuntary movement

维生素B12缺乏主要导致贫血和脊髓亚急性联合变性。此两种表现常能被早期诊断,及时治疗并逆转症状。但是,维生素B12缺乏尚可引起舞蹈症、震颤、肌阵挛、帕金森样症状、肌张力障碍等多种不自主运动而不能被及早诊断和治疗,导致不可逆损害。文中对近20年文献报道的33例维生素B12缺乏性不自主运动的特征予以总结,并对可能机制的研究予以综述,以提高临床医师的认识。

Vitamin B12 deficiency mainly leads to anemia and subacute combined degeneration of the spinal cord. These two manifestations can often be diagnosed early, treated in time and reversed. However, vitamin B12 deficiency can cause a variety of involuntary movements such as chorea, tremor, myoclonus, Parkinson-like symptoms, and dystonia, which are ignored by clinicians and cannot be treated early, resulting in irreversible damage. Therefore, in this paper, the characteristics of 33 cases of vitamin B12 deficiency with involuntary movement in recent 20 years are summarized and the possible mechanisms are reviewed to improve the understanding of clinicians.