借精准医学之力深化前列腺癌的多学科综合治疗

Using the theory of precision medicine to optimize the multidisciplinary comprehensive treatment of prostate cancer

近年来,中国前列腺癌的发病率及死亡率均迅速上升,在部分地区已成为男性前5位常见恶性肿瘤。多学科综合治疗是提升前列腺癌生存率和患者生活质量的关键,以往多基于肿瘤的累及范围、疾病的治疗阶段、临床试验的药物用量构建多学科综合治疗模式,缺乏对肿瘤个体化复杂情景的应对。随着精准医学的突飞猛进,将分子影像、分子分型和药物基因组学内容纳入多学科综合治疗体系中,有助于提升多学科综合治疗的个体化水准。这种精准化的多学科综合治疗,迫切需要从理念、人员和研究层面进一步深化和推进。

In recent years, morbidity and mortality of prostate cancer in China have increased rapidly, and it has become a common malignant tumor among the top 5 male tumors in some areas. Multidisciplinary comprehensive treatment is the key to improve the survival rate and quality of life of prostate cancer. However, the drugs used to construct multidisciplinary comprehensive treatment were based on anatomy, treatment stage and clinical trials, which lacked individualized treatment for complex tumor scenarios. With the rapid development of precision medicine, molecular imaging, molecular typing and pharmacogenomics will be added to these three elements, which will help to improve the individualized level of multidisciplinary comprehensive treatment. This kind of precise multidisciplinary comprehensive treatment urgently needs the vigorous promotion of ideas, researchers and researches.