摘要
严重创伤、大面积深度烧伤可导致与脓毒症、多器官功能衰竭相关的显著的免疫抑制。树突细胞(DC)作为专职抗原呈递细胞和免疫应答的激活因子,在启动和调节先天免疫及适应性免疫反应中发挥着重要作用。本文对DC细胞在创伤/烧伤后数量、功能变化及相关分子机制与逆转措施进行综述,以期为深入研究创伤/烧伤后DC细胞的变化规律,发掘创伤/烧伤的有效干预措施提供参考。
Severe trauma or massive deep burn can cause significant immunosuppression associated with sepsis and multiple organ failure. Dendritic cell (DC), as the professional antigen presenting cells and activating factor of immune response, plays an extraordinary role in initiating and regulating congenital and adaptive immune response. The quantity, functional changes, relevant molecular mechanisms and reverse measures of DC after trauma/burn were reviewed in order to intensively study the changes of DC after trauma/burn and provide a reference for exploring effective intervention measures for trauma/burn.
作者
王星玉
唐欣
陈涛
梁华平
Wang Xingyu;Tang Xin;Chen Tao;Liang Huaping(Department of Intensive Care Unit,the Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou,China;State Key Laboratory of Trauma,Burns and Combined Injury,Research Institute of Surgery,Daping Hospital,the Army Military Medical University,Chongqing 400042,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2019年第4期495-497,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金(81671906)
重庆市基础科学与前沿技术研究项目(cstc2017jcyjAX0159).
关键词
创伤
烧伤
树突细胞
Trauma
Burn
Dendritic cell
