Icotinib plus osimertinib overcome epidermal growth factor receptor 19del/T790 M/C797S/V834L quadruplet resistance mutation in a patient with non-small cell lung cancer

To the Editor:A 66-year-old woman presented with a severe cough and was admitted into hospital in April 2014.Positron emission tomography/computed tomography (PET/CT) scan showed a 2.0 cm×2.0 cm node located on the lower lobe of left lung,multi-mediastinal lymph nodes enlargement and pleural effusion [Figure 1A].