异丙托溴铵联合沙丁胺醇及布地奈德雾化吸入治疗小儿毛细支气管炎的临床疗效

Clinical effect of ipratropium bromide combined with salbutamol and budesonide inhalation for infantile bronchiolitis

目的探讨异丙托溴铵联合沙丁胺醇及布地奈德雾化吸入治疗小儿毛细支气管炎的临床疗效。方法选取茂县人民医院2016年1月—2018年1月收治的小儿毛细支气管炎患儿76例,采取随机数字表法分为对照组与观察组,各38例。对照组患儿予以布地奈德+沙丁胺醇雾化吸入治疗,观察组患儿予以布地奈德+沙丁胺醇+异丙托溴铵雾化吸入治疗,两组患儿均治疗7 d。比较两组患儿临床疗效、体征(喘憋、咳嗽、气促、肺部哮鸣音)消失时间及住院时间,并观察两组患儿不良反应发生情况。结果观察组患儿治疗总有效率高于对照组,喘憋、咳嗽、气促、肺部哮鸣音消失时间及住院时间短于对照组(P<0.05)。两组患儿均未出现严重不良反应。结论异丙托溴铵联合沙丁胺醇及布地奈德雾化吸入治疗小儿毛细支气管炎的临床疗效确切,可有效缓解患儿临床症状,缩短住院时间。

Objective To discuss the clinical effect of ipratropium bromide combined with salbutamol and budesonide for infantile bronchiolitis.Methods A total of 76 cases of children with bronchiolitis were selected from January 2016 to January 2018 in Maoxian People's Hospital,which were randomly divided into control group and observation group,38 cases in each group.The control group was treated with budesonide and salbutamol,the observation group was treated with budesonide, salbutamol and ipratropium bromide.The two groups were treated for 7 days.Clinical effect,physical signs(wheezing,cough, shortness of breath,lung wheezing)extinction time and length of stay were compared between the two groups,and the incidence of adverse reactions were observed.Results The observation group of total effective rate was higher than control group,physical signs(wheezing,cough,shortness of breath,lung wheezing)extinction time and length of stay days were shorter than control group(P<0.05).There were no serious adverse reactions between the two groups.Conclusion Ipratropium bromide combined with salbutamol and budesonide have an exact clinical effect for infantile bronchiolitis,it can effectively relieve the clinical symptoms of children and shorten the ength of stay days.