门冬氨酸钾镁联合胺碘酮治疗急性心肌梗死室性心律失常的临床疗效及其安全性

Clinical efficacy and safety of potassium magnesium aspartate combined with amiodarone for ventricular arrhythmia in acute myocardial infarction

目的探讨门冬氨酸钾镁联合胺碘酮治疗急性心肌梗死(AMI)室性心律失常的临床疗效及其安全性。方法选取韶山市人民医院2017年1月—2018年1月收治的AMI室性心律失常患者60例,根据就诊先后顺序分为对照组和观察组,各30例。对照组患者给予胺碘酮治疗,观察组患者在对照组基础上给予门冬氨酸钾镁治疗。比较两组患者临床疗效、治疗前后心功能指标〔心脏每搏量(SV)、左心室收缩压(LVPS)、左心室射血分数(LVEF)、N末端B型利钠肽前体(NT-proBNP)、心肌肌钙蛋白I(CTnI)〕,并比较两组患者心律失常发生率和不良反应发生率。结果观察组患者总有效率高于对照组(P<0.05)。治疗前两组患者SV、LVPS、LVEF、NT-proBNP、CTnI比较,差异无统计学意义(P>0.05);治疗后观察组患者SV、LVPS、LVEF高于对照组,NT-proBNP、CTnI低于对照组(P<0.05)。观察组患者心律失常发生率、不良反应发生率低于对照组(P<0.05)。结论门冬氨酸钾镁联合胺碘酮治疗AMI室性心律失常的临床疗效确切,可有效改善患者心功能,降低心律失常发生率,且安全性较高。

Objective To investigate the clinical efficacy and safety of potassium magnesium aspartate combined with amiodarone for ventricular arrhythmia in acute myocardial infarction.Methods A total of 60 AMI patients with ventricular arrhythmia were selected from January 2017 to January 2018 in Shaoshan People’s Hospital,which were divided into control group and observation group according to the order of visits,30 cases in each group. The control group was treated with amiodarone,while the observation group was treated with potassium magnesium aspartate based on control group.The clinical effect and SV,LVPS,LVEF,NT-proBNP,CTnI before and after treatment were compared between the two groups,and the incidence of arrhythmia and adverse reactions were compared between the two groups.Results The total effective rate in observation group was higher than control group(P<0.05).There was no significant differences in SV,LVPS,LVEF,NTproBNP or CTnI between the two groups before treatment(P>0.05);after treatment,the observation group of SV,LVPS and LVEF were higher than control group,NT-proBNP and CTnI were lower than control group(P<0.05).The observation group incidence of arrhythmia and adverse reactions were lower than control group(P<0.05).Conclusion Potassium magnesium aspartate combined with amiodarone has definite clinical efficacy for ventricular arrhythmia in AMI,which can effectively improve cardiac function,reduce the incidence of arrhythmia,and with high safety.