阿托伐他汀联合针刺治疗脑卒中后轻度认知障碍的效果观察

Effect of atorvastatin combined with acupuncture in the treatment of mild cognitive impairment after stroke

目的观察阿托伐他汀钙片联合针刺治疗对脑卒中后轻度认知障碍患者应激氧化反应及脑血流动力学的影响。方法选取医院2015年1月-2017年1月收治的脑卒中后轻度认知障碍患者300例,根据不同治疗方法分为观察组和对照组各150例。对照组给予阿托伐他汀钙片治疗,观察组在对照组基础上给予针刺治疗。对比2组患者临床疗效、治疗前后应激氧化反应指标及脑循环动力学指标变化情况。结果观察组患者总有效率为80.67%高于对照组的54.67%,差异有统计学意义(χ~2=15.4495,P<0.05)。治疗前2组OX-LDL及8-iso-PGF2α水平比较差异均无统计学意义(P>0.05);治疗前后观察组OX-LDL及8-iso-PGF2α水平比较差异均无统计学意义(P>0.05);治疗后对照组患者OX-LDL、8-iso-PGF2α水平均高于治疗前及观察组,差异均有统计学意义(P<0.05)。治疗前2组R、Qmean、Vmean比较差异均无统计学意义(P>0.05);治疗后观察组患者R水平低于治疗前及对照组,Qmean、Vmean水平均高于治疗前及对照组,差异均有统计学意义(P<0.05)。结论阿托伐他汀钙片联合针刺方案可有效改善脑卒中后轻度认知障碍。

Objective To observe the effects of atorvastatin combined with acupuncture on stress oxidative response and cerebral hemodynamics in patients with mild cognitive impairment after stroke.Methods 300 patients with mild cognitive impairment after stroke from January 2015 to January 2017 were selected.According to different treatment methods,they were divided into observation group and control group,each of 150 cases.Control group was treated with atorvastatin,and observation group was given acupuncture treatment on the basis of control group.The clinical efficacy,stress oxidation index and cerebral circulation dynamics index changes before and after treatment of two groups were compared.Results The total effective rate in observation group was 80.67% higher than 54.67% in control group,the difference was statistically significant(χ~2=15.4495,P<0.05).There were no significant differences in the levels of OX-LDL and 8-iso-PGF2α between two groups before treatment(P>0.05).There was no significant difference in the levels of OX-LDL and 8-iso-PGF2α before and after treatment in observation group(P>0.05);After treatment,the levels of OX-LDL and 8-iso-PGF2α in control group were higher than those before treatment and observation group,and the difference was statistically significant(P<0.05).There were no significant differences in R,Qmean and Vmean between two groups before treatment(P>0.05).After treatment,the R level of observation group was lower than that before treatment and control group,the Qmean and Vmean levels were higher than before treatment and control group,and the difference was statistically significant(P<0.05).Conclusion Atorvastatin combined with acupuncture can effectively improve mild cognitive impairment after stroke.