泮托拉唑、奥曲肽用于消化性溃疡伴上消化道出血患者治疗中的疗效观察

Clinical effect of pantoprazole and octreotide on peptic ulcer patients with upper gastrointestinal bleeding

目的观察消化性溃疡伴上消化道出血患者予以泮托拉唑联合奥曲肽治疗的临床效果。方法选择消化性溃疡伴上消化道出血患者70例,随机分为观察组和对照组,每组35例。对照组给予泮托拉唑单用治疗,观察组给予泮托拉唑联合奥曲肽治疗,比较2组总有效率、症状消除时间、不良反应发生率。结果观察组治疗总有效率为97. 1%,高于对照组的80. 0%(P <0. 05);观察组大便潜血转阴、引流液清澈、呕血停止、胃镜示止血时间均短于对照组(P <0. 05); 2组不良反应发生率比较差异无统计学意义(P> 0. 05)。结论消化性溃疡伴上消化道出血患者应用泮托拉唑、奥曲肽联合治疗,可提高总有效率,缩短出血、呕血等症状消除时间,且安全性高,临床实用价值明显。

Objective To observe the clinical effect and prognosis of pantoprazole plus octreotide in the treatment of peptic ulcer with upper gastrointestinal bleeding. Methods Seventy patients with peptic ulcer accompanied by upper gastrointestinal bleeding were randomly divided into observation group and control group, 35 cases in each group. The control group was treated with pantoprazole, while the observation group was treated with pantoprazole and octreotide. The total effective rate, symptoms elimination time and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 97. 1%, which was higher than 80. 0% of the control group ( P < 0. 05). The time of occult blood turning negative in stool, clear drainage fluid, stop of hematemesis and gastroscopy hemostasis in the observation group were shorter than those in the control group ( P <0. 05 ). There was no significant difference in the incidence of adverse reactions between the two groups ( P >0. 05). Conclusion Pantoprazole combined with octreotide in the treatment of peptic ulcer with upper gastrointestinal hemorrhage can improve the total effective rate, shorten the elimination time of symptoms such as hemorrhage and vomiting, with high safety and outstanding clinical guidance value.