麻醉相关药物对CD4^+CD25^+Foxp^3+调节性T细胞影响的研究进展

The research progresses on the effect of anesthesia-related drugs on CD4^+CD25^+Foxp^3+ regulatory T cell

CD4^+CD25^+Foxp^3+调节性T细胞(regulatory T cells, Treg)是近年来围手术期免疫功能变化的新兴关注点。Treg有望成为评价围手术期免疫功能的指标。文章综述Treg的生理作用、其数量和功能改变后引起的相关疾病及麻醉相关药物对Treg的影响。进一步了解围手术期麻醉相关药物对免疫功能的影响,可为麻醉医师了解和评价患者围手术期免疫功能变化和临床合理使用麻醉相关药物提供重要依据。

CD4^+CD25^+Foxp^3+ regulatory T cells(Treg) are new focuses during perioperative immune function changes. Although several issues need to be addressed, Treg-based monitor method is a promising evaluation modality that is applicable to a wide use of perioperative immune appraising. To evaluate the perioperative changes of immune function and to provide an important basis for the rational use of anesthesia-related drugs. The article discusses recent findings regarding Treg, including the physiological roles they play, how these cells are involved in the pathophysiology of common diseases and how anesthesia-related drugs affect them.