纳洛酮联合门冬氨酸鸟氨酸治疗老年急性酒精中毒

Effect of Naloxone Combined with L-ornithine-L-aspartate on Acute Alcohol Intoxication in Older Patients

目的探讨老年急性酒精中毒患者给予门冬氨酸鸟氨酸联合纳洛酮治疗的临床有效性。方法抽取2015年11月.2017年9月出现老年急性酒精中毒现象进入本院的患者83例,随机分为联治组43例,给予门冬氨酸鸟氨酸+纳洛酮治疗,单治组40例给予纳洛酮治疗,记录其疗效、安全性,肿瘤坏死因子-α(TNF-α)、β-内啡肽(β-EP)、谷草转氨酶(AST)、谷丙转氨酶(ALT)等指标。结果联治组有效率95.35%(41/43),高于单治组的72.50%(29/40),差异显著,有统计学意义(P<0.01);联治组有3例(6.98%)出现不良反应,与单治组4例(10.00%)比较,差异无统计学意义(P>0.05);联治组用药后TNF-α、β-EP、AST及ALT指标均优于单治组,差异有统计学意义(P<0.01)。结论急诊科在老年急性酒精中毒患者治疗时,给予门冬氨酸鸟氨酸联合纳洛酮治疗效果显著,推荐临床上应用。

Objective To explore the effect of naloxone combined with L-ornithine-L-aspartate on acute alcohol intoxication in older patients. Methods 83 older patients with acute alcohol intoxication between November 2015 and September 2017 were enrolled in the hospital. They were randomly divided into the combination drug group (43 cases) treated with L-ornithine-L-aspartate and naloxone and single drug group (40 cases) treated with naloxone alone. The efficacy, safety, the levels of tumor necrosis factor-α(TNF-α),β-endorphin (β-EP), aspartate aminotransferase ( AST) and alanine aminotransferase ( ALT) were recorded. Results The response rate [95.35%(41/43)] in the combination drug group was higher than that in the single drug group [(72.50%(29/40)]. There were significant differences between the two groups (P<0.01). There were 3 cases (6.98%) with adverse reaction in the combination drug group and 4 cases (10.00%) in the single drug group. There were no significant differences between the two groups (P> 0.05). The levels of TNF-α,β-EP, AST and ALT were lower in the combination drug group than those in the single drug group (P< 0.01). Conclusion Naloxone combined with L-ornithine-L-aspartate is effective in the treatment of acute alcohol intoxication in older patients.