纳米脂肪及其衍生物在抗衰老领域的应用进展

The Application Progress of Nanofat and Its Derivatives for Anti-aging Field

衰老是指随着年龄的增长,机体结构和功能出现退行性改变的过程,在皮肤软组织中主要表现为皮肤质地改变,脂肪萎缩、肌肉体积及弹性改变等。随着研究的不断深入,针对皮肤软组织的抗衰老技术也越来越多。自2013年TonnardP提出纳米脂肪概念并将其应用于改善细纹后,近年来出现了多种纳米脂肪衍生物的报道,由于其含有更多高质量的脂肪干细胞及其它活性成分而被迅速应用于临床。本文通过查阅近年相关文献,对纳米脂肪及其衍生物的制备、成分与其在抗衰老中的临床应用进行综述。

Aging refers to the process of degenerative changes of structure and function in a body as growing older. The main manifestations of aging in soft tissues were changes in skin texture, atrophy of fat and muscle and elasticity decrease of muscle. Continuous research indicates that anti-aging technology for skin and soft tissue was also increasing. Since Tonnard P introduced the concept of nanofat in 2013 and applied it to improve wrinkles, many kinds of nanofat derivatives had been reported in recent years, which was being rapidly applied to clinic because it contains more high-quality adipose stem cells and other cytokines. In this review, the preparation, composition and clinical application of nanofat and its derivatives in anti-aging area were summarized by consulting related literatures in recent years.