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艾拉莫德对老年类风湿关节炎的疗效及其骨代谢分析 被引量:6

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摘要 目的:探究老年类风湿关节炎患者行艾拉莫德治疗的效果及对患者骨代谢指标的影响。方法:择取76例老年类风湿关节炎患者为研究对象,根据完全随机法将其分为对照组与观察组,每组38例。对照组患者行甲氨蝶呤治疗,观察组行甲氨蝶呤联合艾拉莫德治疗,对两组患者临床疗效以及治疗前后骨代谢指标进行比较。结果:观察组患者临床疗效(92.11%)显著高于对照组(73.68%),差异有统计学意义(P<0.05);治疗前两组患者骨代谢指标差异无统计学意义(P>0.05),治疗后两组患者25羟维生素D[25(OH)D]水平差异无统计学意义(P>0.05),观察组患者N端中段骨钙素(N-MID)、总I型前胶原氨基端前肽(T-PINP)水平相比对照组显著更高,β-Ⅰ型胶原羧基端肽(β-CTX)相比对照组显著更低,差异均有统计学意义(P<0.05)。结论:艾拉莫德对老年类风湿关节炎患者具有良好的治疗效果,同时可有效纠正患者骨代谢指标,因此该种治疗方法值得在临床中进行推广。
出处 《吉林医学》 CAS 2019年第6期1269-1270,共2页 Jilin Medical Journal
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  • 1Mucke HAM.Iguratimod:A new disease-modifying antirheumatic drug[J].Drugs of Today,2012,48(9):577.
  • 2Kloesch B, Becker T, Dietersdorfer E, et al. Anti-inflamma- tory and apoptotic effects of the polyphenol eurcumin on human flbroblast-like synovioeytes[J]. Int Immunopharmacol, 2013, 15 (2): 400-405.
  • 3Azizi G, Boghozian R, Mirshafiey A. The potential role of angio- genic factors in rheumatoid arthritis[J]. In~ 3 Rheum Dis, 2014, 17(4): 369-383.
  • 4Zhu Z, Yin Y, Zheng K, et al. Evaluation of synovial an- giogenesis in patients with rheumatoid arthritis using 68Ga- PRGD2 PET/CT: a prospective proof-of-concept cohort study[J].Ann Rheum Dis,2014, 73(6) : 1269-1272.
  • 5Kim SJ, Chen Z, Chamberlain ND, et al. Angiogenesis in rheumatoid arthritis is fostered directly by Toll-like receptor 5 ligation and indirectly through interleukin-17 induction [J]. Arthritis Rheum, 2013, 65(8): 2024-2036.
  • 6Seong AR, Yoo JY, Choi K, et al. Delphinidin, a specific inhibitor of histone acetyhransferase, suppresses inflammatory signaling via prevention of NF-KB acetylation in fibroblast-like synovioeyte MH7A cells[J]. Biochem Biophys Res Commun, 2011, 410(3): 581-586.
  • 7Kalinski T, Sel S, Htitten H, et al. Curcumin blocks inter- leukin-1 signaling in chondrosareoma cells[J]. PLoS One, 2014, 9(6) : e99296.
  • 8Feng X, Lv C, Wang F, et al. Modulatory effect of 1,25- Dihydroxy-vitamin D3 on IL-1 beta-induced RANKL, OPG, TNF- alpha, and IL-6 expression in human rheumatoid synoviocyte MH7A[J]. Clin Dev Immunol, 2013, 2013: 160123.
  • 9Luo Q, Sun Y, Liu W, et al. A novel disease-modifying an- tirheumatic drug, ignratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide[J]. J Immunoh 2013, 191(10): 4969-4978.
  • 10Hu W, Xia LJ, Chen FH, et al. Recombinant human endostatin inhibits adjuvant arthritis by down-regulating CEGF expression and suppression of TNF-alpha, IL-1 beta production[J]. Inflamm Res,2012, 61(8): 827-835.

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