内镜黏膜下剥离术对早期胃癌患者辅助性T细胞17相关因子及预后的影响

The effect of Endoscopic Submucosal Dissection on the Related Factors and Prognosis of Adjuvant T Cell( Th17) in Patients with Early Gastric Cancer

目的探究内镜黏膜下剥离术对早期胃癌患者辅助性T细胞17(Th17)相关因子及预后的影响。方法选取我院收治的早期胃癌患者82例,分为行胃癌根治术的对照组和行内镜黏膜下剥离术的治疗组,各41人,比较两组患者在治疗前后外周血中辅助性T细胞17/效应T细胞(Th17/CD4+T)细胞比例以及血清中白介素-23(IL-23)、白介素-17(IL-17)的水平,同时统计患者术后并发症发生情况。结果治疗组外周血中Th17/CD4+T细胞比例和血清中IL-23、IL-17水平较对照组患者均有显著的下降(P<0.05);治疗组患者并发症发生率(9.76%)明显低于对照组患者(36.59%),差异显著(P<0.05)。结论内镜黏膜下剥离术能够降低早期胃癌患者Th17细胞和其相关因子的水平,对机体的免疫损伤较小,同时在预后方面有更加优秀的表现,能够有效减少并发症的发生。

Objective To investigate the effect of endoscopic submucosal dissection on the related factors and prognosis of adjuvant T cell (Th17) in patients with early gastric cancer. Methods 82 Cases of early gastric cancer in our hospital from January 2015 to January 2018 were selected, the control group and endoscopic submucosal dissection were divided into 41 patients in each group, and the helper T cell 17/T cells in peripheral blood of two groups were compared before and after treatment (Th17/ CD4+ T) cell proportions and levels of IL-23 and IL-17 in the serum, and statistical analysis of postoperative complications of patients, through follow-up statistics to analyze the cure rate and mortality, after comparison. Results The percentage of Th17/CD4+ T cells in the peripheral blood of the treatment group and the levels of IL-23 and IL-17 in the serum were significantly lower than those in the control group ( P <0.05). The incidence of complications in the treatment group (9.76%) was significantly lower than that in the control group (36.59%), P <0.05. Conclusion Endoscopic submucosal dissection can reduce the level of TH17 cells and related factors in patients with early gastric cancer, the immune damage to the organism is smaller, and the prognosis has better performance.