高蛋白饮食通过调控肠道菌群影响肥胖相关研究进展

Research Progress in High Protein Diet Regulating Gut Microbes to Influence Obesity

肠道菌群与肥胖症的发生、发展密切相关,饮食模式可通过影响宿主的肠道菌群参与机体能量代谢,进而发挥减重作用。高蛋白饮食不仅能改变肠道菌群的组成结构与肠道微生态的多样性,在肠道内还可被菌群进一步分解产生色氨酸、吲哚、5-羟色胺等一系列代谢产物,对人体的脑-肠轴及肠道黏膜免疫发挥调控作用,可有效降低肥胖患者体重,并改善机体的慢性低度炎症与代谢状态,为肥胖症的防治提供新的思路。

Gut microbes play an important role in the occurrence and development of obesity.Diet intervention can make an influence on energy metabolism through gut microbes and as a result,lead to weight loss.On one hand,high-protein diet can greatly change the composition and diversity of gut microbes;on the other hand,its microbiome- associated metabolites such as tryptophan,indole and serotonin,actively participate in the regulation of brain-gut axis as well as intestinal mucosal immunity,which can effectively reduce the body weight and at improve the inflammation and metabolic state of obese patients,providing new ideas for the prevention and treatment of obesity.