龋病微生态改善疗法的研究进展

Research Progress in Microbiota Modification Therapy for Caries

龋病是在以细菌为主的多因素作用下,牙体硬组织发生慢性、进行性破坏的一种疾病。随着口腔微生态学的发展,人们逐渐意识到龋病并非某种特定微生物感染所致,而是口腔微生态失衡的结果。研究口腔微生态必须依赖于不断改进的口腔微生物研究方法,这些方法中最主要的有传统平板分离培养法和现代分子生物学法。口腔微生态研究表明,免疫策略、益生菌疗法及中药防龋等微生态改善疗法,可以使口腔微生态重新达到平衡,从而达到预防龋病的效果。

Caries is a chronic bacterial disease affected by multifactors,causing progressive destruction of the tooth structure.With the development of the microecology,people gradually realized that caries is not a particular microbial infection,but an oral micro-ecological imbalance.The study of oral microecology must rely on the continuous improvement of oral microbiologic research methods,the most important of which are traditional plate isolation culture technique and modern molecular biologic method.Oral micro- ecological research results show that the use of immune strategy,probiotic therapy and traditional Chinese medicine and other micro-ecological improvement therapy can make the oral micro-ecology rebalanced,thus achieving the effect of preventing caries.