肠道菌群与2型糖尿病的相关性研究进展

Research Progress in Correlation between Intestinal Flora and Type 2 Diabetes Mellitus

2型糖尿病(T2DM)作为最常见的内分泌代谢性疾病,主要由遗传和环境因素相互作用引起,其发病率逐年升高。肠道微生物即肠道菌群,是人体内最复杂、菌群种类数量最多的微生态系统,与人体建立了互惠互利的动态关联,维持人体正常的免疫反应、新陈代谢等生理功能。肠道菌群作为重要的环境因素参与T2DM的发生、发展,其潜在机制受到了越来越多的关注。肠道菌群与T2DM的相关性研究可为T2DM的预防和治疗提供新的方向。

Type2 diabetes mellitus (T2DM),as the most common endocrine metabolic disease,is mainly caused by the interaction of genetic and environmental factors,and its incidence is increasing year by year.Intestinal microorganisms,also called intestinal flora,is the most complex and most abundant micro-ecological system in the human body.It establishes a mutually beneficial and dynamic relationship with human organisms to maintain normal physiological responses such as immune response and metabolism.The intestinal flora is closely related to the occurrence and development of T2DM,and the potential mechanisms are receiving increasing attention.The correlation between intestinal flora and T2DM may provide a new direction for the prevention and treatment of T2DM.