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全膝关节置换术中布比卡因脂质体镇痛的研究进展 被引量:4

Research Progress in Clinical Use of Bupivacaine Liposomes in Tostal Knee Arthroplasty
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摘要 全膝关节置换术(TKA)后疼痛是影响患者满意度和住院时间的主要因素。目前临床实践指南建议采用多模式疼痛管理方案,包括使用局部麻醉、椎管内麻醉及周围神经阻滞等。关节周围注射在TKA后可提供满意的疼痛缓解。近年来布比卡因脂质体作为传统局部麻醉剂的长效替代物被引入,如布比卡因及罗哌卡因。布比卡因脂质体是一种缓释制剂,用于在最初应用后72h内提供局部止痛。关节周围注射布比卡因脂质体的疗效显著依赖于细致的注射技术。 Pain after total knee arthroplasty(TKA) is a major factor affecting patient satisfaction and length of hospital stay.Current clinical practice guidelines recommend a multimodal pain management program that includes local anesthesia,spinal anesthesia,and peripheral nerve block.Injection after TKA around the joint provides satisfactory pain relief.In recent years, bupivacaine liposomes have been introduced as long-acting alternatives to traditional local anesthetics,such as bupivacaine and ropivacaine.Bupivacaine liposomes are a sustained release formulation designed to provide local analgesia within 72 h of initial application.The efficacy of bupivacaine liposomes around the joints is significantly dependent on careful injection techniques.
作者 李航 王文波 LI Hang;WANG Wenbo(Department of Orthopedics,the First Affiliated Hospital of Harbin Medical University,Harbin150001,China)
出处 《医学综述》 2019年第10期2044-2048,共5页 Medical Recapitulate
关键词 全膝关节置换术 布比卡因脂质体 镇痛 术后疼痛 Total knee arthroplasty Bupivacaineliposomes Analgesia Postoperative pain
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