髓源性抑制细胞在乳腺癌发生中的作用及调控机制

Biological function and mechanism of MDSCs in breast cancer

髓源性抑制细胞(myeloid-derived suppressor cells,MDSCs)可以削弱癌症免疫治疗的效果,甚至造成治疗失败。在乳腺癌中,MDSCs主要由乳腺癌细胞募集,从而形成抑制抗肿瘤免疫的微环境。此外,MDSCs可以直接与乳腺癌细胞相互作用。研究表明,MDSCs在乳腺癌发生发展中发挥了免疫抑制作用,进而促进肿瘤血管生成,引起肿瘤耐药和肿瘤转移。因此,阻断MDSCs募集并抑制其功能将会改善乳腺癌的免疫治疗效果。本文将MDSCs在乳腺癌中的生物学功能及调控机制作一综述。

Myeloid-derived suppressor cells(MDSCs)could weaken the efficacy of immunotherapy for cancer,and even result in the failure of cancer treatment.In breast cancer,MDSCs are recruited mainly by breast cancer cells forming a tumor-favor microenvironment to suppress the anti-tumor immune response.Besides,MDSCs could directly interact with breast cancer cells.Recent studies reveal that MDSCs can not only promote the growth and development of breast cancer,but also angiogenesis,drug resistance and metastasis through suppressing anti-tumor immune response.Regarding to the pivotal role of MDSCs in breast cancer,eliminating MDSCs and attenuating its activity might facilitate the treatment of breast cancer.This review will focus on reviewing biological functions and regulatory mechanisms of MDSCs in the progress of breast cancer.