IL-17F基因多态性和儿童哮喘易感性相关性分析

TAssociation between IL-17 F gene polymorphism and susceptibility to asthma in children

目的探讨IL-17F基因多态性和哮喘易感性、IL-17水平的关系。方法选择133例哮喘患儿和114例对照儿童,测定IL-17F基因rs763780、rs1889570位点多态性,并分析其与儿童支气管哮喘易感性及外周血IL-17水平的相关性。结果哮喘组和对照组两组间等位基因、基因型频数分布在rs 1889570位点的差异有统计学意义(P=0.049、P=0.043),哮喘组携带A等位基因者明显高于对照组(OR=1.43,95%CI:1.001~2.004,P=0.049);rs 763780位点等位基因、基因型分布在两组间的差异均无统计学意义(P>0.05)。哮喘组rs 763780和rs 1889570位点各基因型间IL-17水平差异均无统计学意义(P>0.05)。结论IL-17F基因rs 1889570位点与儿童哮喘易感性有关,携带A等位基因者发生哮喘的危险性高。

Objective To explore the relationship of IL-17F gene polymorphism with asthma susceptibility and IL-17F level.Method The single nucleotide polymorphisms of rs763780 and rs1889570 in IL-17F gene were determined in 133 asthma children and 114 control children,and the correlation among the polymorphisms and the susceptibility and peripheral blood IL-17 level in children with bronchial asthma were analyzed.Results The frequency of alleles and genotypes in rs1889570 were significantly different between asthma patients and healthy controls(P=0.049,P=0.043).The A allele frequency of rs1889570 in asthma group was signi ficantly higher than that in control group(OR=1.43,95%CI:1.001~2.004,P=0.049).The frequency of alleles and genotypes in rs763780 between two groups had no significant difference(P>0.05).There was no difference in IL-17 levels between rs763780 and rs1889570 genotypes in asthma group(P>0.05).Conclusion The rs1889570 locus of IL-17F gene is associated with the susceptibility to asthma in children and those who carry the A allele are at high risk of asthma.