FHIT及Ki67在膀胱尿路上皮癌中的表达及与意义

Expression and Significance of FHIT and Ki67 in Bladder Urothelial Carcinoma

目的:观察FHIT及Ki67蛋白在膀胱尿路上皮癌组织中的表达及相关性。方法:采用免疫组织化SP法检测66例膀胱癌和42例正常膀胱组织中FHIT及Ki67蛋白表达情况,利用Spearman相关性分析对FHIT与Ki67蛋白进行相关性分析。结果:FHIT蛋白在正常膀胱组织中的阳性率为92.85%,在膀胱尿路上皮癌中的阳性表达率为39.39%;而Ki67则相反;在膀胱尿路上皮癌中的表达率为90.91%;在正常膀胱组织中表达率为11.90%;FHIT和Ki67蛋白的异常表达与膀胱尿路上皮癌临床分期、分化程度有关。Spearman相关性分析显示,FHIT与Ki67蛋白表达呈负相关。结论:联合检测FHIT和Ki67,有助于提高膀胱尿路上皮癌侵袭能力的评估,有助于膀胱尿路上皮癌临床预后判断。

Objective To observe the expression and correlation of FHIT and Ki67 protein in bladder urothelial carcinoma tissue.Methods The expression levels of FHIT and Ki67 protein in 66 cases of bladder cancer and 42 cases of normal bladder tissue were detected by immunohistochemical SP.Spearman correlation analysis was used to analyze the correlation between FHIT and Ki67 protein.Results The positive rate of FHIT protein was 92.85%in normal bladder tissue,and the positive rate in bladder urothelial carcinoma was 39.39%;Ki67 was the opposite,the expression rate in bladder urothelial carcinoma tissue was 90.91%,the expression rate in normal bladder tissue was 11.90%,while the abnormal expression of Ki67 and FHIT protein was related to the clinical stage and differentiation of bladder urothelial carcinoma.Spearman correlation analysis showed that FHIT was negatively correlated with Ki67 protein expression.Conclusion FHIT combined with Ki67 is detected helpful to evaluate the invasion ability and clinical prognosis of bladder urothelial carcinoma.