发酵法生产纳豆激酶的研究进展

Advances in the Production of Nattokinase by Fermentation

纳豆激酶是一种从纳豆中提取的蛋白酶,具有显著的体内外溶栓活性,有望开发成为新一代溶栓药物。目前,纳豆激酶主要通过微生物发酵制得,但发酵产率不高阻碍了其进一步开发。主要从菌种选育和发酵工艺这2个生产关键环节进行综述,为其进一步开发提供了参考。

Nattokinase is a protease extracted from natto with significant in vitro and in vivo thrombolytic activity and is expected to be developed into a new generation of thrombolytic drugs.At present,nattokinase is mainly produced by microbial fermentation,but the low yield of fermentation hinders its further development.This paper mainly summarized the two key production steps of strain selection and fermentation process,and provided reference for its further development.