上海某郊区成年居民脂肪肝和代谢综合征的患病情况及影响因素分析

Fatty liver disease and metabolic syndrome in adults from Shanghai suburb area: Prevalence and risk factors

【目的】了解上海市郊区成年居民脂肪肝和代谢综合征的患病情况,并分析其潜在的影响因素。【方法】选取于2017年5—9月期间在上海市松江区某社区接受体检的20~74岁常驻居民,开展常规体格检查、B超影像学检查、临床血液学检验及问卷调查,根据B超结果诊断脂肪肝,根据体格检查和临床血液指标诊断代谢综合征,分析脂肪肝和代谢综合征的患病率及其影响因素。【结果】共纳入分析6608人中,脂肪肝患病率为38.29%(男性31.29%,女性42.67%,P<0.001),代谢综合征患病率为36.40%(男性32.94%,女性38.56%,P<0.001)。脂肪肝和代谢综合征均更易发生在女性、高年龄段、超重或肥胖、既往曾患有高血压、糖尿病或高血脂等疾病的人群中,更高的受教育水平和过轻的体质指数则为两者的保护性因素。脂肪肝和代谢综合征互为高危影响因素。【结论】上海市松江区脂肪肝的患病率远高于文献报道,而代谢综合征的患病率维持在高位,需引起高度重视。

[Objective]To investigate the prevalence of fatty liver disease(FLD)and metabolic syndrome(MetS)in adults from Shanghai suburb area,and to explore the risk factors of FLD and MetS.[Methods]Adults aged 20~74 years old from a community of Shanghai Songjiang district were invited to take medical examination,B-ultrasonography,clinical blood test and questionnaire investigation.FLD was diagnosed based on ultrasound image,and MetS diagnosed based on the physical examination and blood test according to criteria from the Modified National Cholesterol Education Program Adult Treatment Panel(mATPⅢ2005).The data thus obtained were used to analyze the prevalence and risk factors of FLD and MetS.[Results]Among the 6 608 participants being investigated,the prevalence of FLD was 38.29%(males 31.29%,females 42.67%,P<0.001),and the prevalence of MetS was 36.40%(males 32.94%,females 38.56%,P<0.001).FLD and MetS were more prevalent in females and participants having higher age,overweight or obesity,and having the history of high blood pressure,diabetes mellitus or hyperlipidemia.Better education and underweight were the protective factors of FLD and MetS.The FLD was the risk factor of MetS,and vice versa.[Conclusion]The prevalence of FLD in Songjiang district of Shanghai is higher than that in the data from literature,and the prevalence of MetS is maintains at the high level.High concern needs to be raised because of the high prevalence of FLD and MetS.