探讨尼可地尔对慢性缺血性心肌病患者心脏功能的影响

Discussion on effect of nicorandil on cardiac function in patients with chronic ischemic cardiomyopathy

目的探讨尼可地尔对慢性缺血性心肌病患者心脏功能的影响。方法 80例慢性缺血性心肌病患者,随机分为试验组和对照组,每组40例。对照组采取常规治疗,试验组在对照组基础上使用尼可地尔治疗。比较两组患者左心室射血分数(LVEF)、6 min步行距离、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)水平。结果治疗后,试验组患者的LVEF(57.55±6.43)%、6 min步行距离(493.59±75.98)m、LVEDD(51.18±6.21)mm、LVESD(45.39±3.18)mm均优于对照组的(45.69±5.87)%、(435.82±79.92)m、(55.23±6.04)mm、(53.58±2.78)mm,差异均具有统计学意义(P<0.05)。结论慢性缺血性心肌病患者使用尼可地尔进行治疗,能够明显改善患者的心脏功能,值得在临床推广。

Objective To discuss the effect of nicorandil on cardiac function in patients with chronic ischemic cardiomyopathy. Methods A total of 80 patients with chronic ischemic cardiomyopathy were randomly divided into experimental group and control group, with 40 cases in each group. The control group received conventional therapy, and the experimental group received nicorandil for treatment on the basis of the control group. Comparison were made on left ventricular ejection fraction (LVEF), 6-min walking distance, left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) between the two groups. Results After treatment, the experimental group had better LVEF as (57.55±6.43)%, 6-min walking distance as (493.59±75.98) m, LVEDD as (51.18±6.21) mm and LVESD as (45.39±3.18) mm than (45.69±5.87)%,(435.82±79.92) m,(55.23±6.04) mm and (53.58±2.78) mm in the control group. Their difference was statistically significant (P<0.05). Conclusion Nicorandil in patients with chronic ischemic cardiomyopathy can significantly improve their cardiac function, and it is worthy of clinical promotion.