双源CT联合血清TSH在判断甲状腺结节性质中的应用价值

Application value of dual-source CT combined with serum thyroid-stimulating hormone in diagnosis of thyroid nodules

目的探讨双源CT联合血清TSH对判断甲状腺结节性质的应用价值。方法选择102例甲状腺结节患者作为研究对象,入选患者均进行甲状腺双源CT、甲状腺功能及病理检查,根据病理检查结果分为恶性甲状腺结节组59例与良性甲状腺结节组43例,比较2组患者的双源CT碘值和血清TSH检测结果。以病理检查结果为金标准,分析双源CT或血清TSH单一检测与联合检测对判断甲状腺结节性质的诊断效能。结果2组患者甲状腺结节碘值均低于甲状腺结节周围正常组织碘值(P<0.05);恶性甲状腺结节组甲状腺结节碘值低于良性甲状腺结节组(P<0.05)。恶性甲状腺结节组血清TSH高于良性甲状腺结节组(P<0.05)。联合检测对甲状腺结节性质的诊断符合率高于TSH单一检测(P<0.017)。以病理结果为金标准,双源CT与血清TSH联合检测的灵敏度、阴性预测值高于双源CT或血清TSH单一检测(P均<0.017)。结论双源CT与血清TSH联合检测对判断甲状腺结节性质具有较高诊断价值。

Objective To investigate the application value of dual-source computed tomography (CT) combined with serum thyroid-stimulating hormone (TSH) detection in the diagnosis of thyroid nodules.Methods A total of 102 patients with thyroid nodules were selected as the study subjects. All patients received dual-source CT, thyroid function and pathological examinations. All patients were assigned into the malignant (n = 59) and benign thyroid nodule groups (n = 43). The results of dual-source CT and TSH detection were statistically compared between two groups. Pathological examination outcomes were regarded as the gold standard to compare the diagnostic efficiency among dual-source CT, serum TSH and two combined in assessing the nature of thyroid nodules.Results The iodine value of the normal tissues around the thyroid nodules was significantly higher than that of the thyroid nodules (P < 0.05). The iodine value of the malignant thyroid nodules was remarkably lower compared with that of the benign thyroid nodules (P < 0.05). The serum TSH level in the malignant thyroid nodules was significantly higher than that in the benign thyroid nodules (P < 0.05). The consistency rate of two combined was considerably higher than that of TSH detection alone (P < 0.017). Pathological examination outcomes were considered as the gold standard. The sensitivity and negative predictive value of two combined was remarkably higher compared with those of dual-source CT or serum TSH detection alone (all P < 0.017).Conclusion Dual-source CT combined with serum TSH detection yields high diagnostic value in evaluating the nature of thyroid nodules.