口腔疾病致病因素诱导表观遗传改变研究进展

Advances in epigenetic changes induced by pathogenic factors of oral diseases

口腔是一个复杂而又完整的生态系统,除了微生物群落外,解剖结构、温度、湿度、pH、营养源、蛋白酶以及外来因素等均影响着这个生态系统。正常情况下这个生态系统与宿主之间保持着一种动态平衡,但是,由于影响因素众多,所以这个动态平衡是脆弱的,某一因素的异常改变均能打破这种平衡,从而引起口腔疾病。越来越多的研究证实了遗传因素在口腔疾病病因学中的作用。随着人们对口腔疾病发病机理的认识,口腔疾病的致病因素诱导表观遗传改变被更多的人关注。本文综述了细菌、病毒、细胞因子等口腔疾病致病因素诱导的表观遗传变化在口腔疾病发病机制中所起的关键作用,有助于相关药物的开发及应用。

The oral cavity is a complex and complete ecosystem. In addition to the microbial community, anatomical structure, temperature, humidity, pH, nutrient sources, proteases, and external factors all influence the ecosystem. Under normal circumstances, this ecosystem maintains a dynamic balance with the host. However, due to the large number of influencing factors, this dynamic balance is fragile. Abnormal changes in a certain factor can disrupt this balance and cause oral cavity disease. Increasing studies have confirmed the role of genetic factors in the etiology of oral diseases. With the understanding of the pathogenesis of oral diseases, the pathogenic factors induced by oral diseases have attracted more attention. This article reviews the key role of epigenetic changes induced by pathogenic factors, such as bacteria, viruses,and cytokines, in the pathogenesis of oral diseases and contributes to the development and application of related drugs.