锦州地区乙型肝炎病毒DNA检验与年龄性别关系的研究

Research on the Relation Between Hepatitis B DNA Testing and Age and Gender in Jinzhou Area

目的分析锦州地区人群乙型肝炎病毒(HBV)定量检测和患者年龄性别的关系,为临床患者制定治疗策略提供一定依据。方法收集2016年6月至2018年5月期间来锦州医科大学附属第一医院就诊患者2960例,对其阳性率和病毒定量与患者年龄、性别的关系进行分析。结果2960例患者阳性率60.47%。男性阳性率62.28%(630/1670)大于女性阳性率58.34%(537/1289),χ^2=4.77,P<0.05。通过趋势卡方检验比较各年龄段阳性率,差异具有统计学意义χ^2=32.58,P<0.005,总体呈现下降的趋势。不同年龄段患者高病毒定量例数<30岁年龄组高于31~98年龄组,差异有统计学意义χ^2=48.04,P<0.005。不同年龄段患者低病毒量组差异具有统计学意χ^2=20.42,P<0.05成n字形分布。结论乙型肝炎DNA病毒量在不同年龄、性别都差异具有统计学意义,为临床患者制定治疗策略提供一定依据。

Objective To analyze the relationship between the quantitative detection of hepatitis B virus (HBV) and the age and sex of the patients in Jinzhou area so as to provide some basis for formulating the treatment strategies for clinical patients. Methods 2960 patients who visited the First Affiliated Hospital of Jinzhou Medical University from June 2016 to May 2018 were collected,and the relation between their positive rate and virus quantification and age and gender was analyzed. Results The positive rate of 2960 patients was 60.47%. The male positive rate was 62.28%(630/1670),while the female positive rate was 58.34%(537/1289),with a statistically significant difference(χ^ 2=4.77, P <0.05). The positive rate of each age group was compared by trend chi-square test,with a statistically significant difference(χ^2=32.58, P <0.005),showing an overall downward trend. The number of high viral quantitative cases in different age groups was smaller than group of 30 years old and greater than that in 31~98 age group,with statistically significant difference(χ^2=48.04, P <0.005). The difference of low viral dose in different age groups was statistically significant (χ^ 2=20.42, P <0.05),in n-shaped distribution. Conclusion The amount of HBV DNA virus varies with age and gender and the difference is statistically significant,providing a basis for formulating treatment strategies for clinical patients.