HOXB7基因在胃癌中的表达及预后价值

Prognostic value of expression of HOXB7 in gastric cancer

背景胃癌(gastric cancer, GC)是严重危害人体健康的恶性肿瘤,其发病率和死亡率分别占世界恶性肿瘤的第5位和第3位,因此,寻找GC治疗的新靶点和预后的新标志对改善患者预后至关重要.目前, HOXB7在GC中的表达及预后价值鲜有报道.目的分析HOXB7基因在GC中的表达模式及预后价值.方法利用Oncomine数据库分析HOXB7基因在GC及正常胃黏膜组织中的表达.利用KM Plotter数据库分析HOXB7表达与预后的关系.结果对Oncomine数据库中关于GC和正常胃黏膜组织HOXB7基因芯片数据集进行分析发现GC组织中HOXB7基因的表达显著高于正常胃黏膜组织,差异有统计学意义(P<0.05).进一步分析发现HOXB7基因在肠型GC和弥漫型GC中的表达均显著高于正常胃黏膜组织. KM Plotter数据库分析显示, GC组织中HOXB7高表达与患者总体生存率显著相关(P<0.05).且HOXB7高表达与不同亚型GC患者(Lauren亚型)总体生存率仍显著相关(P<0.05).结论 HOXB7的表达变化可能是正常胃黏膜上皮转变为GC的重要分子生物学事件,HOXB7或可作为GC预后的标志物.

BACKGROUND Gastric cancer(GC) is the fifth most common cancer and the third leading cause of cancer death worldwide.Identifying new targets for the treatment and predictive evaluation of GC is of great significance, especially for improving the prognosis. Few studies have focused on the clinical significance of homeobox B7(HOXB7) expression in GC. AIM To assess the prognostic value of HOXB7 expression in GC. METHODS HOXB7 data were retrieved from the Oncomine GC database. The prognostic value of HOXB7 was assessed using an online survival analysis tool(KM Plotter database). RESULTS Based on the Oncomine database, HOXB7 expression in GC was significantly higher than that in normal tissue(P<0.05). Further analysis revealed that the expression of HOXB7 gene in both intestinal and diffuse GCs was significantly higher than that in normal tissue. Moreover, KM Plotters of overall survival indicated that high HOXB7 expression was closely associated with poor survival in GC(P<0.05). Furthermore, high HOXB7 expression was also related with overall survival in different GC subtypes(Lauren subtype)(P<0.05). CONCLUSION High HOXB7 expression might be an important biological event during gastric oncogenesis, and could be a novel prognostic predictive factor for GC.