芪味理肺汤治疗急性发作期支气管哮喘临床研究

The Clinical Research into Bronchial Asthma at Acute Attack Stage Treated with Lung-Nourishing Decoction plus Astragalus

目的:观察芪味理肺汤治疗急性发作期支气管哮喘的临床疗效及其对相关因子的影响。方法:选择本院急性发作期支气管哮喘患者78例,随机均分为对照组和观察组各39例,对照组采用常规西药治疗,观察组在对照组治疗的基础上联合芪味理肺汤治疗,疗程均为2周。比较两组患者治疗前后咳嗽、喘息、肺部哮鸣音和湿啰音、呼吸困难的中医证候积分,临床疗效;肺功能:用力肺活量(forced vital capacity,FVC)、1秒用力呼气容积(forced expiratory volume in one second,FEV1)、最大呼气流量(peak expiratory flow,PEF);血清炎症因子:白细胞介素-2(interleukin-2,IL-2)、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白细胞介素-6(interleukin-6,IL-6)和白细胞介素-10(interleukin-10,IL-10);免疫功能:Th1/Th2。结果:两组患者治疗后各项中医证候积分及总积分均较治疗前降低(P <0. 05),且观察组明显低于对照组,差异有统计学意义(P <0. 05);对照组有效率为74. 4%,观察组有效率为92. 3%,两组有效率比较,差异有统计学意义(P <0. 05);两组患者治疗后FVC、FEV1、PEF值均较治疗前增加,观察组FVC、FEV1、PEF值明显高于对照组,差异有统计学意义(P <0. 05);两组患者治疗后血清IL-2和TNF-α、Th1/Th2均较治疗前升高,IL-6和IL-10均较治疗前降低,观察组改善程度优于对照组,差异有统计学意义(P <0. 05)。结论:芪味理肺汤治疗成人急性发作期支气管哮喘有较好的安全性和有效性,可调节机体的免疫功能,减轻炎症反应。

Objective: To observe the clinical curative effect of Lung-Nourishing Decoction plus Astragalus on bronchial asthma at acute attack stage and its influence on related factors. Methods: A total of 78 patients with acute attack of bronchial asthma treated in our hospital were randomly divided into the control group and the observation group,with 39 cases in each group. The ones in the control group were treated with conventional Western medicine,while the ones in the observation group were treated with Lung-Nourishing Decoction plus Astragalus on the basis of the control group. The course of treatment lasted 2 weeks. The TCM syndrome scores of cough,wheezing,wheezing,moist rale and dyspnea,and the clinical efficacies before and after the treatment were compared between the two groups. The following before and after the treatment were also compared: Lung functions: forced vital capacity( FVC),forced expiratory volume in one second( FEV1),peak expiratory flow( PEF);Serum inflammatory factors:interleukin-2( IL-2),Tumor Necrosis Factor( TNF-α),Interleukin-6( IL-6) and Interleukin-10( IL-10);Immune function:Th1/Th2. Results: After the treatment,the scores of TCM syndromes and total scores of the two groups were lower than those before the treatment,the observation group was lower than the control group,and all the differences were statistically significant( P < 0. 05). The effective rate of the control group was 74. 4%,and that of the observation group was 92. 3%. And the difference was statistically significant( P < 0. 05). The FVC,FEV1 and PEF values of the two groups were higher than those before the treatment,the observation group was higher than the control group,and all the differences were statistically significant( P < 0. 05).The serum IL-2,TNF-α,Th1/Th2 of the two groups were higher than those before the treatment,while IL-6 and IL-10 were lower than those before the treatment,and the improvement degree of the observation group was better than that of the control group,And all the differences were statistically significant( P < 0. 05). Conclusion: In terms of treating acute attack of bronchial asthma,Lung-Nourishing Decoction plus Astragalus has good safety and effectiveness,can regulate the immune function of the body and reduce inflammation.