摘要
在PPh3催化下,橙酮和联烯酸酯可通过陆氏[3+2]环化反应成功构建含有螺[1-苯并呋喃-3-酮-2,5'-环戊烯]的多环结构单元.该反应条件温和,操作简单,并且底物适用性好,产率高.该方法学的研究为applanatumin A等天然产物的合成奠定了基础.
The PPh3 catalyzed Lu's[3+2] annulation of aurones with alkenoates has been developed to form spiro-[1-ben-zofuran-3-one-2,5'-cyclopentene] polycyclic moiety. The usefulness of this strategy has been demonstrated by the use of a wide variety of substrates to give desired polycyclic compounds in high yield under mild and simple reaction condition. This methodology research offered a fine entry for synthesis of natural product applanatumin A and its analogues.
作者
苏瀛鹏
冯亚威
曹林丹
薛文轩
石娅
常兵兵
黄丹凤
王克虎
胡雨来
Su Yingpeng;Feng Yawei;Cao Lindan;Xue Wenxuan;Shi Ya;Chang Bingbing;Huang Danfeng;Wang Ke-Hu;Hu Yulai(College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第5期1333-1343,共11页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21502154,21362033)
甘肃省科技计划(No.17JR5RA073)资助项目~~