摘要
综合运用多种现代色谱学分离方法对红树来源真菌Penicillium citrinum HL-5126中的次级代谢产物进行了研究,从中分离获得2个新的异香豆素类化合物,通过1D NMR,2D NMR和HR-ESI-MS等波谱鉴定技术确定结构分别为penicimarin J(1)和penicimarin K(2).通过测定圆二色谱并与文献数据对照,确定了化合物1和2的绝对构型.化合物1和2对α-Glucosidase显示一定的抑制活性,IC50值分别为18.37和25.86μg/mL.
Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against α-glucosidase with the IC50 values of 18.37 and 25.86 μg/mL, respectively.
作者
梅荣清
黄国雷
王斌
白猛
罗由萍
陈光英
郑彩娟
Mei Rongqing;Huang Guolei;Wang Bin;Bai Meng;Luo Youping;Chen Guangying;Zheng Caijuan(Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第5期1479-1482,共4页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(Nos.21462015,31760093)
the National Natural Science Foundation of Hainan Province(No.218MS045)
the Program for Innovative Research Team in University(No.IRT-16R19)~~
