氨氯地平和赖诺普利治疗老年高血压的经济学评价——基于Markov模型

Economic Evaluation of Amlodipine and Lisinopril in the Treatment of Senile Hypertension——Based on Markov Model

目的:对氨氯地平和赖诺普利治疗老年高血压进行经济学研究,评价老年高血压用药的安全有效性和经济性。方法:构建氨氯地平和赖诺普利治疗老年高血压Markov模型,动态模拟疾病发展;对模型进行回乘分析、队列分析,获取两种药物治疗老年高血压的成本和效果,并进行敏感性分析,查看结果的稳定性。结果:氨氯地平治疗方案累积成本和健康效用分别为63 372.61元和13.5QALYs,赖诺普利治疗方案的累积成本和健康效用分别为68788.68元和13.44QALYs,氨氯地平更具成本效果;敏感性分析显示,各参数在设定的范围内变化不影响模型结果。结论:对老年高血压患者来说,选择氨氯地平更具成本效果。

Objective To conduct an economic study on the treatment of senile hypertension with amlodipine and lisinopril,and to evaluate the safety,efficacy and economy of senile hypertension medication. Methods Amlodipine and lisinopril were used to treat the senile hypertension Markov model,and to simulate disease development dynamically. The model was analyzed by back-multiplication analysis and cohort analysis to obtain the cost and effect of two drugs for the treatment of senile hypertension,and the sensitivity analysis was performed to check the stability of the results. Results The cumulative cost and health effects of amlodipine treatment were 63 372.61 yuan and 13.5 QALYs,respectively. The cumulative cost and health effects of lisinopril treatment were 68 788.68 yuan and 13.44 QALYs,respectively. Amlodipine was more cost effective.Sensitivity analysis showed that changes in the parameters within the set range did not affect the model results. Conclusion Amlodipine is more cost effective for senile hypertensive patients.