蝉翼藤根茎中的1个新半萜苷

A new hemiterpene glycoside from rhizomes of Securidaca inappendiculata

目的研究蝉翼藤Securidaca inappendiculata根茎中的化学成分。方法采用大孔树脂、硅胶柱色谱、中压液相、凝胶色谱以及高效制备液相色谱等手段对蝉翼藤根茎95%乙醇提取物中甲醇部位进行分离纯化,根据所得化合物的理化性质和波谱数据鉴定其结构。结果从蝉翼藤根茎中分离得到5个化合物,分别鉴定为2-methylene-butanoicacid4-O-[(β-Dglucopyranosyl)oxy]-intramol-1,6′-ester(1)、3-甲氧基-4-O-β-D-吡喃葡萄糖基-苯甲酸甲酯(2)、苏式-4,7,9,9′-四羟基-3,3′-二甲氧基-8,4′-氧新木脂烷-4-O-β-D-吡喃葡萄糖苷(3)、eucomegastigside A(4)、毛果槭倍半新木脂醇-4″-O-β-D-吡喃葡萄糖苷(5)。结论化合物1为1个新的半萜苷,命名为蝉翼藤萜酸苷D。化合物2～4为首次从远志科植物中分离得到。

Objective To study the chemical constituents from the rhizomes of Securidaca inappendiculata. Methods The concrete exacted by 95% Et OH from the rhizomes of S. inappendiculata was isolated and purified by chromatography on macroporous resin, silica gel, MPLC, gel, preparative HPLC, etc. The structures of the chemical constituents were elucidated by means of physicochemical properties and spectroscopic analysis. Results Five compounds were isolated and identified as 2-methylene-butanoic acid 4-O-[(β-D-glucopyranosyl)oxy]-intramol-1,6′-ester(1), 3-methoxyl-4-O-β-D-glucopyranosyloxy-benzoic acid methyl ester(2), threo-4,7,9,9′-tetrahydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-D-glucopyranoside(3), eucomegastigside A(4), and acernikol-4″-O-β-D-glucopyranoside(5). Conclusion Compound 1 is a new hemiterpene glycoside named securiterpenoside D, and compounds 2-4 are isolated from Polygalaceae for the first time.