矮石斛化学成分研究

Chemical constituents of Dendrobium bellatulum

目的研究兰科石斛属植物矮石斛Dendrobium bellatulum的化学成分。方法采用各种柱色谱及制备液相色谱分离纯化,经波谱数据鉴定化合物结构。结果从矮石斛全草甲醇提取物中分离得到15个化合物,分别鉴定为2-羟基-4-甲氧基-3,6-二甲基苯甲酸(1)、4′,5-二羟基-3,3′-二甲氧基联苄(2)、3,3′-二羟基-4,5-二甲氧基联苄(3)、二氢松柏醇二氢对羟基桂皮酸酯(4)、aloifolI(5)、山药素Ⅲ(6)、dendrosinenB(7)、2,5,7-三羟基-4-甲氧基-9,10-二氢菲(8)、对羟基苯丙酸(9)、对羟基肉桂酸(10)、阿魏酸(11)、咖啡酸(12)、dendrosinen D(13)、新橄榄树脂素(14)、3-羟甲基-9-甲氧基-2-(4′-羟基-3′,5′-二甲氧基苯基)-2,3,6,7-四氢菲[4,3-b]呋喃-5,11-二醇(15)。结论化合物1～15均为首次从该植物中分离得到,其中化合物1为首次从兰科植物中分离得到。

Objective To study the chemical constituents of Dendrobium bellatulum. Methods The compounds were isolated and purified by column chromatography and preparative HPLC, and their structures were elucidated by spectral analysis. Results Fifteen compounds were isolated and identified as 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid(1), 4′,5-dihydroxy-3,3′-dimethoxybiphezyl(2), 3,3′-dihydroxy-4,5-dimethoxybiphezyl(3), dihydroconiferyl dihydro-p-coumarate(4), aloifol I(5), batatasin Ⅲ(6), dendrosinen B(7), 2,5,7-trihydroxy-4-methoxy-9,10-dihydrophenanthrene(8), p-hydroxyphenyl-propionic acid(9),p-hydroxycinnamic acid(10), ferulic acid(11), caffeic acid(12), dendrosinen D(13), neoolivil(14), and 3-hydroxymethyl-9-methoxy-2-(4′-hydroxy-3′,5′-dimethoxyphenyl)-2,3,6,7-tetrahydrophenanthro [4,3-b] furan-5,11-diol(15). Conclusion All compounds are isolated from D. bellatulum for the first time, and compound 1 is isolated from the family Orchidaceae for the first time.