穴位埋线治疗糖尿病前期的Meta分析

Meta-analysis of Acupoint Embedding for Pre-diabetes

目的:系统评价穴位埋线治疗糖尿病前期的临床疗效。方法:检索穴位埋线治疗糖尿病前期的临床随机对照试验(randomized controlled trial,RCT)。由2位研究者根据纳入和排除标准,独立提取资料后,采用RevMan 5.3软件进行Meta分析。结果:8个RCT纳入Meta分析,共计791例患者。Meta分析结果显示:试验组在提高糖尿病前期患者临床有效率[RR=1.31,95%CI(1.11,1.54),P=0.001]、降低空腹血糖[MD=-0.47,95%CI(-0.80,-0.13),P=0.007]、降低餐后2小时血糖[MD=-0.54,95%CI(-0.90,-0.18),P=0.003]、降低糖化血红蛋白[MD=-0.74,95%CI(-1.22,-0.27),P=0.002]等方面均优于对照组。敏感性分析显示:Meta分析结果有较好的稳定性。结论:穴位埋线治疗糖尿病前期疗效优于常规综合治疗,可提高患者临床有效率,改善血糖、糖化血红蛋白水平。

Objective:To systematically evaluate the clinical efficacy of acupoint embedding for pre-diabetes.Methods:A randomized controlled trial(RCT) of acupoint embedding for pre-diabetes was retrieved.Meta-analysis was performed using RevMan 5.3 software after two individuals independently extracted data based on inclusion and exclusion criteria.Results:8 RCTs were included in the meta-analysis for a total of 791 patients.Meta-analysis results showed that the experimental group was superior to the control group in improving the clinical efficiency[RR=1.31,95%CI(1.11,1.54),P=0.001],reducing fasting blood glucose [MD=-0.47,95%CI(-0.80,-0.13),P=0.007],reducing blood glucose 2 hours after meal [MD=-0.54,95%CI(-0.90,-0.18),P=0.003],reducing glycated hemoglobin [MD=-0.74,95%CI(-1.22,-0.27),P=0.002] of patients with pre-diabetes.Sensitivity analysis showed that the meta-analysis results had good stability.Conclusion:Acupoint embedding is superior to conventional comprehensive treatment in the treatment of pre-diabetes,which can improve the overall clinical efficiency and improve blood sugar and glycated hemoglobin levels.