摘要
创伤后失血性休克常常与骨折同时发生,由于失血性休克可导致全身性系统改变,而骨折的愈合也是一个需要全身众多因素共同调控的综合过程。因此在失血性休克后骨折的研究中,除了对于骨折本身的治疗,其对于骨折愈合的影响也同样应受到重视。目前失血后导致的骨折不良愈合机制仍存有空白和争议,本文针对这个容易被临床忽视的角度,全面综述相关临床和基础研究,旨在为临床面对失血性休克后骨折不良愈合患者提供参考,也为进一步研究其内在机制启发新的研究思路。
Hemorrhagic shock often occurs simultaneously with fractures. Hemorrhagic shock is related to systemic changes in human body, and fracture healing is a comprehensive process involved numerous factors in the body. Therefore in addition to the treatment of the fracture, its impact on fracture healing should also be taken seriously in the study of fractures after hemorrhagic shock. At present, the mechanism of poor fracture healing caused by blood loss is still elusive. We comprehensively review relevant clinical and basic researches in view of this easily overlooked clinical issue, aiming to provide a reference for dealing with patients with poor fracture healing after hemorrhagic shock clinically. It also inspired new research ideas for further research on the exact mechanisms of hemorrhagic shock and fracture healing.
作者
祝晟
Andreas Nüssler
Sheng Zhu;Andreas Nussler(Department of Trauma and Reconstructive Surgery,Siegfried Weller Institute for Trauma Research,Eberhard Karls University Tuebingen,BG Trauma Center Tuebingen,Tuebingen ,Germany)
