唾液的采集与分析及其与口腔疾病关系的研究进展

Research progress in saliva collection, analysis and its relationship with oral diseases

唾液是口腔唾液腺分泌的一种重要的生物液体,其所含的生物分子十分丰富,可随着机体健康状况改变,且获取方式比血液更方便无创,使得唾液在口腔疾病的检测方面有重要的意义。目前,唾液组学研究的不断深入以及高灵敏度、高通量和无偏向性的唾液成分分离分析技术的应用,为在唾液中快速寻找部分口腔疾病生物标志物提供了可能。本文对唾液的采集与成分分析方法,以及唾液与口腔疾病的关系进行综述,以期为进一步研究提供参考。

As one of the major body fluid, saliva has various components that can shift according to the systemic health state. With the atraumatic way of collection, saliva can be a promising media to help the detection of oral diseases. With the development of salivaomics and the application of unbiased, highly sensitive, and high throughout separation techniques for salivary components, there′s now more possibilities for effective identification of biomarkers correlated with oral diseases. This review aimed to introduce the current state of saliva collection and detection techniques as well as their correlation with oral diseases, hoping to provide evidence for further research.