分泌性中耳炎与咽鼓管黏膜超微结构和分子生物学的关系

Relationship between otitis media with effusion and ultrastructure and molecular biology of the Eustachian tube mucosa

分泌性中耳炎是临床上的常见病和多发病,对儿童听力和言语发育影响较大,咽鼓管功能障碍是其明确的发病原因之一。正常状态下的咽鼓管黏膜是咽鼓管实现功能的重要组成部分,对维持中耳腔良好微环境,保持其正常功能至关重要。咽鼓管黏膜超微结构和分子生物学上的异常与分泌性中耳炎的发生存在密切联系。因此本文综述对比近年来咽鼓管黏膜正常和分泌性中耳炎下的超微结构和分子生物学差异,进一步探讨分泌性中耳炎的发病机制,以期对指导临床治疗有所帮助。

Otitis media with effusion is one of the most common diseases in children and infants, which is a major cause of childhood morbidity increasing the risk for hearing lossand the delay in language development. Eustachian tube dysfunction is one of the clear causes of the disease. The eustachian tube mucosa under normal conditions is an important part of the eustachian tube function, which is essential for maintaining a good microenvironment in the middle ear cavity and maintaining its normal function. Ultrastructural and molecular biological abnormalities of the eustachian tube mucosa are closely related to the occurrence of otitis media with effusion. Therefore, this article reviews the ultrastructural and molecular biological differences between normal and otitis media with effusion eustachian tube mucosa in recent years, and further explores the pathogenesis of secretory otitis media, in order to help guide clinical treatment.