胚胎移植失败患者负性情绪与生活质量的相关性研究

Correlation between negative emotion and quality of life in patients with embryo transfer failure

目的调查接受体外受精-胚胎移植多次胚胎移植失败患者焦虑抑郁及生活质量现状,并分析两者相关性。方法选取2018年5月至2018年11月在杭州市妇产科医院生殖中心接受体外受精-胚胎移植的80例多次胚胎移植失败患者为研究对象,采用患者基本情况调查表、中文版生育生活质量问卷(FertiQoL)和焦虑自评量表(SAS)、抑郁自评量表(SDS)进行横断面调查,分析其焦虑抑郁情绪、生育生活质量现状及相关性。结果多次胚胎移植失败患者整体生育生活质量评分为(52.82±16.14)分,各领域中精神/躯体领域得分最低,为(43.58±22.71)分,治疗耐受性位于其次,为(44.88±20.54)分,治疗环境领域得分最高,为(64.17±14.52)分;多次胚胎移植失败患者SAS得分为(48.00±9.42)分,高于接受辅助生殖技术非多次胚胎移植失败患者的(42.67±7.30)分,差异有统计学意义(t=6.53,P<0.01);多次胚胎移植失败患者SDS得分为(52.00±11.91)分,仍高于接受辅助生殖技术非多次胚胎移植失败患者的(44.00±9.72)分,差异有统计学意义(t=7.36,P<0.01);Pearson相关分析显示:焦虑得分与生育生活质量总得分呈显著负相关性(r=-0.71,P<0.01);抑郁得分与生育生活质量总得分呈显著负相关性(r=-0.72,P<0.01)。结论接受辅助生殖技术且多次胚胎移植失败患者的生活质量较低,其焦虑抑郁情绪发生率较高,且焦虑抑郁情绪越严重,生活质量越低。

Objective To investigate the status of anxiety, depression and quality of life in patients with multiple embryo transfer failure and to analyze the correlation between them. Methods Eighty patients with multiple embryo transfer failure who received in vitro fertilization-embryo transfer at the reproductive medicine center of Hangzhou Obstetrics and Gynecology Hospital from May to November 2018 were selected as subjects. A cross-sectional survey was conducted using the Patient Basic Situation Questionnaire, the Chinese version of the Fertility Quality Questionnaire(FertiQoL), the Self-rating Anxiety Scale(SAS), and the Self-rating Depression Scale(SDS) to analyze the anxiety, depression, reproductive quality of life and their correlation. Results The overall reproductive quality of life scores of patients with multiple embryo transfer failure was 52.82±16.14, and the score in the mental/somatic field was lowest(43.58±22.71), followed by treatment tolerance(44.88±20.54), and the score in therapeutic environment was highest(64.17±14.52). The SAS score of patients with multiple embryo transfer failure(48.00±9.42) was higher than that of patients who didn’t fail in receiving assisted reproductive techniques(42.67±7.30) with significant difference(t=6.53, P<0.01). The SDS score of patients with multiple embryo transfer failure(52.00±11.91) was still higher than that with non-repeated implants(44.00±9.72), and the difference was statistically significant(t=7.36, P<0.01). Pearson correlation analysis showed that there was a significant negative correlation between anxiety score and total reproductive quality(r=-0.71,P<0.01). There was a significant negative correlation between depression score and total score of reproductive quality(r=-0.72, P<0.01).Conclusion The quality of life of patients receiving assisted reproductive technology and multiple embryo transfer failure is low, and the incidence of anxiety and depression is higher. The more anxiety and depression, the lower the quality of life.