痤疮相关易感基因多态性的研究进展

Research progress of acne-related susceptibility gene polymorphism

痤疮是一种由多基因遗传决定、多种环境因素共同作用引起的毛囊皮脂腺慢性炎症性疾病,其发病机制十分复杂。目前影响痤疮发病的具体基因仍不清楚。随着人类基因多态性的发展,现已证实基因多态性与痤疮的相关性。该文将从各种细胞因子、核转录因子等几个方面阐述痤疮的易感基因多态性的研究现状。

Acne is a chronic inflammatory disease of sebaceous glands and hair follicles, which is caused by polygenic inheritance factors and multiple environmental factors. Its pathogenesis is very complicated. At present, the specific genes that affect the incidence of acne are still unclear. With the development of human genetic polymorphism research, the correlation between gene polymorphism and acne has been confirmed. This article reviews the research status of susceptibility gene polymorphism of acne from several aspects, including various cytokines, insulin-like growth factor-1 and nuclear transcription factors.