艾灸结合中西药对2型糖尿病患者神经内分泌免疫网络紊乱的调节作用研究

Analysis on the Influence of Moxibustion Combines Chinese and Western Medicine the Regulation of Neuroendocrine Immune Network Disorder in Type 2 Diabetic Patients

目的探讨穴位艾灸结合中西药治疗2型糖尿病患者的临床疗效及对患者神经内分泌免疫网络紊乱的调节作用。方法选取我院收治的2型糖尿病患者64例,采用随机数字表法平均分为两组,即对照组与研究组。两组患者均给予中西医治疗,研究组在对照组的基础上加用穴位艾灸,疗程3个月,比较两组患者治疗的有效性和神经内分泌免疫的各项指标。结果研究组总有效率为93.75%(30/32),对照组为78.13%(25/32),两组患者总有效率具有明显差异,P<0.05,研究组患者经治疗后血清DA、NE、IL-1、IL-6及TNF-α的含量较治疗前显著下降,CD4^+、CD8^+及NK细胞数量较治疗前显著上升(P<0.01),且明显优于对照组(P均<0.05),差异具有统计意义。结论穴位艾灸辅助治疗2型糖尿病疗效明显,其机制可能与改善神经内分泌免疫网络紊乱状态有关,对神经内分泌免疫网络紊乱有调节作用,值得推广应用。

Objective To investigate the clinical effect of acupoint moxibustion on the treatment of type 2 diabetes mellitus and its regulation effect on the disturbance of neuroendocrine immune network in patients. Methods A total of 64 patients with type 2 diabetes admitted to our hospital from March 2016 to August 2017 were randomly divided into two groups, the control group and the treatment group, each with 32 cases. Both groups were treated with Chinese and western medicine, and the team used acupoint moxibustion on the basis of the control group for 3 months, to compare the efficacy of treatment in two groups and the indicators of neuroendocrine immunity.Results The total effective rate of treatment group was 93.75%(30/32), while the control group was 78.13%(25/32). The total effective rate of the two groups was significantly different(P< 0.05), and the difference was statistically significant. Treatment group after treatment than before treatment the serum content of DA, NE up;IL-6, IL-1, cut down the content of TNF alpha, CD4^+, CD8^+ and NK cells quantity increased(P< 0.01), and is superior to the control group(P< 0.05), the difference has statistical significance. Conclusion Acupuncture moxibustion auxiliary curative effect in the treatment of type 2 diabetes, its mechanism may be related to improvement of neuroendocrine immune network state of disorder, disorder of neuroendocrine immune network has regulating effect, is worthy of popularization and application.