白蛇地乌方联合臭氧大自血疗法治疗类风湿关节炎的临床疗效

Efficacy of agkistrodon acutus, yehmannia root and radix aconite powder combined with ozone autohemotherapy in the treatment of patients with rheumatoid arthritis

目的观察白蛇地乌方联合臭氧大自血疗法治疗类风湿关节炎患者的临床疗效。方法选择2017年1月至2018年12月陇西县第一人民医院疼痛科住院的类风湿关节炎患者64例,按随机数字表法分为常规药物组(CM组)和白蛇地乌方联合臭氧大自血疗法组(AOM组),每组32例。CM组患者口服尼美舒利0.1g/次,2次/d;复方骨肽注射液100mg静脉滴注,每日1次;口服甲氨蝶呤片7.5mg/次,1次/周,以上药物15d为一个疗程。AOM组患者抽取100ml静脉血入臭氧大自血疗法全封闭血袋,抽取30~50μg/ml臭氧与之充分混合后在10~15min内回输入采血静脉,1次/d,15d为一个疗程;同时白蛇地乌方研粉温水冲服,每次6~8g,3次/d,15d为一个疗程。观察治疗前与治疗后1d、3个月时两组患者的关节晨僵时间、双手握力、关节疼痛指数评分、关节肿胀指数评分、VAS评分、类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)值,并评估疗效。结果与治疗前比较,治疗结束后1d,3个月时两组患者临床症状明显改善(P<0.05);RF、ESR及CRP下降明显(P<0.05)。与CM组比较,AOM组患者治疗后1d时临床症状明显改善(P<0.05);RF、ESR、CRP及VAS下降明显(P<0.05);治疗后3个月时,AOM组晨僵时间缩短明显(P<0.05);AOM组的RF、ESR及CRP下降更明显(P<0.05);AOM组总有效率高于CM组(P<0.05)。结论白蛇地乌方联合臭氧大自血疗法治疗类风湿关节炎是一种有效方法。

Objective To investigate the efficacy of agkistrodon acutus, yehmannia root and radix aconite powder combined with ozone autohaemotherapy in the treatment of rheumatoid arthritis. Methods Sixty-four patients with rheumatoid arthritis from January 2017 to December 2018 in the First People's Hospital of Longxi County, were randomly divided into conventional medicine group (group CM, n=32) and agkistrodon acutus, yehmannia root and radix aconite powder combined with ozone autohaemotherapy group (group AOM, n=32). Patients in group CM were given nimesulide 0.1 g, twice a day orally, compound ossotide injection 100 mg intravenous infusion, once a day, methotrexate tablet 7.5 mg, once a week orally, and the above drugs for 15 days as a course of treatment. In group AOM, 100 ml venous blood was drawn into the completely closed blood bag of ozone autohemotherapy, and 30-50 μg/ml ozone was extracted and fully mixed with it, and then returned to the blood vein within 10-15 min, once a day, 15 days as a course of treatment. At the same time, agkistrodon acutus, yehmannia root and radix aconite powder was taken after mixing it with water, 6-8 g each time, 3 times one day, 15 days as a course of treatment. The time of joint morning stiffness, handgrip strength, score of joint pain index, score of joint swelling index, VAS, rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were observed before and one day, 3 months after the treatment, and the efficacy was evaluated. Results Compared with pre-treatment, the clinical symptoms were significantly improved at 1 day and 3 months after the treatment in two groups (P<0.05);RF, ESR and CRP were decreased significantly (P<0.05). Compared with group CM, there was significant improvement in clinical symptoms at 1 day after the treatment (P<0.05);RF, ESR, CRP and VAS decreased significantly (P<0.05);the morning stiffness time was significantly shortened at 3 months after the treatment (P<0.05);RF, ESR and CRP were significantly decreased in group AOM (P<0.05). The total effective rate of group AOM was higher than that of group CM (P<0.05). Conclusion Agkistrodon acutus, yehmannia root and radix aconite powder combined with ozone autohemotherapy is an effective method in the treatment of patients with rheumatoid arthritis.