中药止痛胶囊联合双氯芬酸钠栓剂对骨折患者术后疼痛的疗效

Efficacy of Chinese alleviating pain capsule (中药止痛胶囊) combined with diclofenac sodium suppository for postoperative analgesia in patients with fracture

目的观察骨折患者术后采用中药止痛胶囊联合双氯芬酸钠栓剂镇痛的效果。方法收集2016年4月至2017年6月在郑州仁济医院行骨折手术患者100例,性别不限,年龄21~73岁,根据单盲抽签法将其分为双氯芬酸钠组、联合用药组,每组50例。双氯芬酸钠组采用双氯芬酸钠栓剂治疗,联合用药组采用中药止痛胶囊与双氯芬酸钠栓剂治疗,观察两组患者用药后6、12、24h时疼痛程度、炎性因子水平、临床疗效及药物不良反应。结果用药后6、12、24h时,联合用药组VAS评分分别为(3.8±0.5)、(1.0±0.4)、(0.8±0.4)较双氯芬酸钠组(5.2±0.7)、(4.1±0.6)、(3.6±0.5)低,差异具有统计学意义(P<0.05);用药后,联合用药组血清白介素-6(IL-6,19.3±2.2)pg/ml、肿瘤坏死因子-α(TNF-α,11.4±2.9)ng/ml、白细胞介素-8(IL-8,13.0±2.1)μg/L水平均较双氯芬酸钠组(24.0±3.2)pg/ml、(18.3±3.2)ng/ml、(16.0±2.1)μg/L低,差异具有统计学意义(P<0.05);联合用药组总有效率较双氯芬酸钠组高,差异具有统计学意义(P<0.05);联合用药组不良反应发生率8%(4/50例),较双氯芬酸钠组6%(3/50例)高,但差异无统计学意义(P>0.05)。结论中药止痛胶囊口服联合双氯芬酸钠栓剂可降低骨折患者术后疼痛程度,减轻炎性反应,且不增加药物不良反应,安全性较高。

Objective To observe the effects of Chinese alleviating pain capsule (中药止痛胶囊) combined with diclofenac sodium suppository in postoperative analgesia of patients with fracture. Methods One hundred patients of both sexes with fracture, aged 21-73 years in Zhengzhou Renji Hospital from April 2016 to June 2017 were collected, and they were divided into diclofenac sodium group and combined group according to the single blind selection method, with fifty cases in each group. The patients were given diclofenac sodium suppository in diclofenac sodium group, while the patients took Chinese alleviating pain capsule orally and diclofenac sodium suppository in combined group. The visual analogue scale (VAS), inflammatory factors, clinical efficacy and adverse reactions were observed at 6, 9, 12 h after the operation in the two groups. Results At 6, 12, 24 h after the treatment, the VAS was lower in the combined group [(3.8±0.5),(1.0±0.4),(0.8±0.4)] than that in the diclofenac sodium group [(5.2±0.7),(4.1±0.6),(3.6±0.5)](P<0.05). After the treatment, the levels of IL-6, TNF-α and IL-8 were lower in the combined group [(19.3±2.2) pg/ml,(11.4±2.9) ng/ml,(13.0±2.1)μg/L] than those in the diclofenac sodium group [(24.0±3.2) pg/ml,(18.3±3.2) ng/ml,(16.0±2.1)μg/L](P<0.05). The total effective rate of the combined group was higher than that of the diclofenac sodium group (P<0.05). The incidence rate of adverse reactions was higher in the combined group [8%(4/50 cases)] than that in the diclofenac sodium group [6%(3/50 cases)], but there was no statistical difference (P>0.05). Conclusion Postoperative pain and inflammatory response factors can be decreased with the use of Chinese alleviating pain capsule combined with diclofenac sodium suppository for patients with fracture after surgery, with higher safety and lower adverse reactions.