丙戊酸钠与左乙拉西坦治疗小儿癫痫的临床疗效分析

Clinical efficacy of sodium valproate and levoethylacetam in the treatment of epilepsy in children

目的对小儿癫痫治疗中丙戊酸钠联合左乙拉西坦的疗效进行探讨。方法选择本院2017年1月至2017年12月收治的80例小儿癫痫患儿作为观察对象,依据随机数字表法分为实验组和常规组,各40例。常规组应用左乙拉西坦治疗,实验组应用丙戊酸钠联合左乙拉西坦治疗,统计并对比两组治疗效果。结果实验组临床疗效均显著优于常规组,组间差异有统计学意义(P<0.05)。实验组脑电图检测结果均显著优于常规组(P<0.05)。治疗后实验组P300潜伏期显著低于常规组(P<0.05)。治疗后实验组MoCA总分显著高于常规组(P<0.05)。两组不良反应发生率对比差异无统计学意义。结论应用丙戊酸钠联合左乙拉西坦治疗小儿癫痫效果显著,能够使患儿认知功能得到有效改善,并且具有较高安全性,值得进行广泛推广。

Objective To investigate the efficacy of sodium valproate combined with levoethylacetam in the treatment of pediatric epilepsy. Methods 80 children with epilepsy from January 2017 to December 2017 in our hospital were selected and randomly divided into experimental group and routine group with 40 cases in each group. The routine group was treated with levoethylacetam and the experimental group was treated with sodium valproate and levoethy lacetam. Results The clinical efficacy of the experimental group was significantly better than that of the routine group, and the difference between the two groups was statistically significant (P<0.05). The results of EEG in the experimental group were significantly better than those in the routine group, and the difference between the two groups was statistically significant (P<0.05). There was no significant difference in P300 latency between the two groups before treatment. After treatment, the latency of P300 in the experimental group was significantly lower than that in the routine group, and the difference between the two groups was statistically significant (P<0.05). There was no significant difference in the total score of MoCA between the two groups before treatment. After treatment, the total score of MoCA in the experimental group was significantly higher than that in the routine group. The difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Aodium valproate combined with levoethoxetam is effective in the treatment of epilepsy in children. It can effectively improve the cognitive function of children and has high safety. It is worth popularizing widely.