西格列汀对2型糖尿病空腹血糖及胰岛β细胞功能影响研究

Effect of sitagliptin on type 2 diabetes mellitus and its effect on islet β cell function

目的探讨西格列汀对2型糖尿病患者空腹血糖及胰岛β细胞功能影响。方法收集本院90例2017年6月至2018年1月2型糖尿病患者。随机分组,对照组予以甘精胰岛素治疗,观察组则予以甘精胰岛素联合西格列汀治疗,比较结果。结果观察组临床疗效高于对照组(P<0.05);观察组血糖控制至达标的天数优于对照组(P<0.05);治疗前两组空腹血糖情况、甘油三酯、总胆固醇差异均无统计学意义;治疗后观察组空腹血糖情况、甘油三酯、总胆固醇优于对照组(P<0.05)。治疗前两组胰岛β细胞功能并无明显差异;治疗后观察组胰岛β细胞功能优于对照组(P<0.05)。观察组低血糖率低于对照组(P<0.05)。结论甘精胰岛素联合西格列汀治疗2型糖尿病的临床疗效确切,可更好改善空腹血糖情况、甘油三酯、总胆固醇、胰岛β细胞功能,值得推广应用。

Objective To investigate the effect of sitagliptin on type 2 diabetes mellitus and its effect on islet β cell function. Methods 90 patients with type 2 diabetes from June 2017 to January 2018 were enrolled in our hospital. Randomly grouped, the control group was treated with insulin glargine, and the observation group was treated with insulin glargine plus sitagliptin. The clinical efficacy of the two groups was compared;the number of days of blood glucose control reached the standard;the fasting blood glucose level, triglyceride and total cholesterol before and after treatment;the islet β-cell function related indicators before and after treatment;the hypoglycemia rate. Results The clinical efficacy of the observation group was higher than that of the control group (P<0.05). The number of days of blood glucose control in the observation group was better than that of the control group (P<0.05). There was no significant difference in fasting blood glucose, triglyceride and total cholesterol between the two groups before treatment. After treatment, the fasting blood glucose, triglyceride and total cholesterol in the observation group were better than the control group (P<0.05). There was no significant difference in islet β-cell function between the two groups before treatment. After treatment, the islet β-cell function was better than the control group (P<0.05). The hypoglycemia rate of the observation group was lower than that of the control group (P< 0.05). Conclusion The clinical efficacy of insulin glargine combined with sitagliptin in the treatment of type 2 diabetes is better, which can improve the fasting blood glucose, triglyceride, total cholesterol and islet β cell function. It is worthy of popularization and application.