雷尼替丁联合多潘立酮治疗小儿消化不良的临床疗效观察

Clinical efficacy of ranitidine combined with domperidone in the treatment of dyspepsia in children

目的观察小儿消化不良采用多潘立酮与雷尼替丁联合治疗的临床效果。方法选取本院2016年10月至2017年10月所收治的消化不良患儿100例,根据患儿床号将其均分为观察组和参照组,每组各50例,参照组患儿给予雷尼替丁单一治疗,观察组患儿给予多潘立酮与雷尼替丁联合治疗,对比观察组与参照组患儿临床症状消失时间、治疗效果、不良反应发生情况。结果观察组不良反应总发生率4%低于参照组20%,组间对比差异有统计学意义(P<0.05)。比较两组患儿治疗效果,观察组总有效率98%高于参照组80%,治疗总有效率对比差异有统计学意义(P<0.05)。观察组患儿食欲减退、上腹疼痛、恶心呕吐、腹胀的临床症状消失时间均短于参照组患儿,组间对比差异有统计学意义(P<0.05)。结论治疗小儿消化不良采用雷尼替丁与多潘立酮联合治疗,其临床症状消失时间较快,对患儿造成的不良反应较少,其临床用药安全性较高,可将该种联合治疗措施广泛推广运用。

Objective To observe the clinical effect of domperidone combined with ranitidine in the treatment of dyspepsia in children. Methods 100 children with dyspepsia admitted to our hospital from October 2016 to October 2017 were enrolled. According to the bed number, the children were divided into observation group and reference group. Each group had 50 cases, and the reference group gave children. Single treatment with ranitidine, combined with domperidone and ranitidine in the observation group, comparing the time of disappearance of clinical symptoms, treatment effect, and adverse reactions in the observation group and the reference group. Results The total incidence of adverse reactions in the observation group was 4% lower than that in the reference group, and the difference between the groups was statistically significant (P<0.05). The therapeutic effect of the two groups were compared. The total effective rate of the observation group was 98%higher than that of the reference group, and the difference in total effective rate was statistically significant (P<0.05). In the observation group, the loss of appetite, upper abdominal pain, nausea and vomiting, and the clinical symptoms of bloating disappeared in the reference group. The difference between the groups was statistically significant (P<0.05). Conclusion The treatment of dyspepsia in children is treated with ranitidine and domperidone. The clinical symptoms disappeared quickly, and the adverse reactions to children were less. The safety of clinical medication was higher, and the combination therapy could be widely promoted. use.