左甲状腺素治疗甲亢患者的疗效及对其各项指标的影响

Therapeutic effect of levothyroxine on hyperthyroidism and its influence on various indicators

目的探讨左甲状腺素治疗甲亢患者的临床疗效及对血清其FT3、FT4、TSH的影响。方法选择2017年6月至2018年5月期间收治的甲亢患者76例为研究对象。随机分为对照组(38例)和观察组(38例)。对照组给予甲巯咪唑片治疗,观察组在对照组基础上给予左甲状腺素钠片治疗。比较两组治疗前治疗后血清FT3、FT4、TSH水平变化及临床疗效。结果两组治疗前血清FT3、FT4、TSH等甲状腺功能指标比较差异无统计学意义;治疗后,两组血清FT3、FT4水平明显减低,TSH水平明显升高,其观察组更加明显(P<0.05);观察组总有效率为92.11%(35/38),明显高于对照组71.05%(27/38)(P<0.05)。结论左甲状腺素可显著降低甲亢患者血清FT3、FT4水平,促进TSH分泌,临床疗效确切,可进行临床推广应用。

Objective To investigate the clinical efficacy of levothyroxine in the treatment of hyperthyroidism and its influence on serum FT3, FT4 and TSH. Methods 76 patients with hyperthyroidism admitted to our hospital from June 2017 to May 2018 were selected as the research subjects. They were divided into control group and observation group by random number table grouping method, with 38 cases in each group. The control group was treated with methimazole tablets, while the observation group was treated with levothyroxine sodium tablets on the basis of the control group. The changes of serum FT3, FT4 and TSH levels and clinical efficacy were compared between the two groups before treatment. Results There was no significant difference in serum FT3, FT4 and TSH between the two groups before treatment;after treatment, serum FT3, FT4 levels were significantly reduced and TSH levels were significantly increased in the two groups (P<0.05);after treatment, serum FT3, FT4 levels in the observation group were significantly lower than those in the control group, and TSH levels were significantly higher than those in the control group (P<0.05). The total effective rate was 92.11%(35/38) in the observation group, which was significantly higher than 71.05%(27/38) in the control group (P< 0.05). Conclusion Left thyroxine can significantly reduce serum FT3 and FT4 levels and promote TSH secretion in patients with hyperthyroidism. The clinical effect is definite and it can be widely used in clinic.