非编码RNA与肝纤维化的研究进展

Research Progress of Non-coding RNA and Liver Fibrosis

肝纤维化是一个病理生理过程,其中细胞外基质在肝组织中的过度沉积和结缔组织的异常增殖是由各种致病因子长期刺激引起的,肝纤维化的本质是一种炎症增生修复反应。许多非编码RNA(ncRNA)与肝纤维化的发生、发展关系密切,其在肝脏细胞的增殖、活化、凋亡、分解及信号通路调节等方面发挥重要作用,探索其在肝纤维化过程中的调控机制,不仅可以进一步熟悉和理解肝纤维化的病理生理过程,还可以寻找合适的分子靶点,为肝纤维化的诊断、治疗和预后提供新思路。

Hepatic fibrosis is a pathophysiological process,in which excessive deposition of extracellular matrix in liver tissue and abnormal proliferation of connective tissue are caused by long-term stimulation of various pathogenic factors,and its nature is an inflammatory proliferation repair response.Recent studies have shown that many non-coding RNAs( ncRNAs ) are closely related to the occurrence and development of hepatic fibrosis, playing important roles in the proliferation and activation of hepatocytes,apoptotic decomposition and signal pathway regulation.Exploring the regulation mechanism of ncRNAs in the process of hepatic fibrosis can not only further familiarize and understand the physiology and patho- logy of hepatic fibrosis,but also bring new ideas for the diagnosis,treatment and prognosis of liver fibrosis through finding suitable molecular targets.